The machine helps keep the oxygen level high enough for healthy tissues.
When patients are placed on the machine for breathing they require a tube to be placed into lungs. These patients need sedation to help them tolerate the uncomfortable breathing tube and other parts of their routine necessary care.
The main question is whether or not one of the drugs is better in a patient with a blood infection. Our main goal is to see whether or not patients on one particular drug come off the breathing machine faster than patients on the other drug. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
These drugs are not experimental drugs and are approved by the Food and Drug Administration. All patients in this study will receive the best possible care based on their medical condition.
Benzodiazepines bind to gamma-aminobutyric acid (GABA) type A receptors.
Gamma-aminobutyric acid is a neurotransmitter that slows the activity of nerves.
Benzodiazepines shorten the time it takes to fall asleep and they increase total sleep time.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its Clinical identifier (NCT number): NCT02203019 Carson SS, Kress JP, Rodgers JE, Vinayak A, Campbell-Bright S, Levitt J, Bourdet S, Ivanova A, Henderson AG, Pohlman A, Chang L, Rich PB, Hall J. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. Pandharipande PP, Sanders RD, Girard TD, Mc Grane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW; MENDS investigators.
When these problems develop, care becomes quite complicated.
Patients with lung failure often need help with a breathing machine to make certain that the breathing is adequate.